Considerations prior to administration
• Patients with pre-existing neurological disorders should be trated cautiously with
fludarabine.1 Higher doses have been associated with CNS toxicity characterised by delayed
blindness, coma and death.
• Fludarabine dosage should be adjusted for patients with renal impairment, though no formal
guidance is available.2,5 Fludarabine should not be given to patients with Creatinine
• Dose limiting toxicity is myelosuppression which can be cumulative1