• Epirubicin hydrochloride.
• Pharmorubicin TM Rapid Dilution
• PharmorubicinTM Solution for Injection
Mechanism of action
Cytotoxic anthracycline antibiotic 1.
Intercalation with DNA results in interruption of DNA replication and transcription
through inhibition of DNA and RNA polymerases. Anthracyclines also interact with
the topoisomerases, causing nucleic acid breaks as a result of interference with the
transcription, repair and recombination of DNA.