3- Hydroxyacetyldaunorubicin 1
Mechanism of action
Doxorubicin is an anthracycline antibiotic active in all phases of the cell cycle with maximal
activity in S phase. It has several modes of action including intercalation to DNA double
helix, topoisomerase II mediated DNA damage, production of oxygen- free radicals which
cause damage to DNA and cell membranes, and complex formation with iron or copper via
the hydroquinone moieties 2. Iron doxorubicin complexes may contribute to cardiotoxicity by
toxic free radical generation 3.